Called GnRH antagonists, these medications work differently than the GnRH agonists like Lupron. 13R. In this regimen, a patient will take BCPs for 3-4 weeks. Now I wait for day 5 and then onto to PGTA testing. Anyone have success with this protocol? (I did not use a lot of what was ordered.) She has already been prescribing me an aggressive protocol (microdose Lu, So a little bit about me. EDD 5/11/14, Jack dx at 19w1d with Dandy Walker on 12/16/13, Severe Pre-e /HELLP set in Jack born sleeping at 20w1d on 12/23/13, FET #2 --July 2014 BFP! Learn more about, Twins & Multiples: Your Tentative Time Table. Stimulation Day 4 Come in for an E2 and LH blood test. Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251. 0000002646 00000 n Since TFC opened its doors more than 40 years ago, we have helped our patients deliver 23,000 miracles through IVF, IUI, egg donation, intracytoplasmic sperm injection, and reconstructive fertility surgery. My AFC was 7 on day 3. What now - IUI, Adoption, Donor Eggs or Donor Embryos, Retire Early?! Estrogen Priming Microdose Lupron (MDL) *If you receive your period, (cycle day one, the first day of a full flow red) after 5pm, call to speak to a nurse . Austin, Texas 78731, 16040 Park Valley Drive Building 1, Ste 201 Team Purple. Thank you. They said my FSH and AMH levels were really good too so i just think i'm a poor responder to IVF in general! sudden, severe decrease in blood pressure and collapse. He's also prescribed microdose lupron, gonal, low dose hcg, and pregnyl. Start Lupron: Start your microdose Lupron 20 units subcutaneous injection twice a day. I am 28. 9dp5dt Beta 1 = 344!! I did 9 IVF attempts in 2 years - high stim, low stim, mid-stim, estrogen-priming. 2TFR'ed. Anyone have anything reassuring to say about it? Your diagnosis of MENTS I just got my calendar today and I'm getting ready to start Lupron. I stimmed for like 15 days, got 5 eggs, 3 fert with icsi, all disintegrated basically, no blasts. Many different stimulation regimens have been developed and evaluated and it is therefore very important for you to discuss your options in detail with your physician. During the first few days of Lupron, the ovaries are stimulated by the natural pituitary hormones (the flare . I just finished day 4 of gonal, microdose and letrozole. NT- all looks good. Is this normal??? :'-( Microdose Lupron Flare Protocol. I have my egg retrieval on Thursday & was curious if anyone had similar timing & wanted to be my buddy. The most commonly prescribed stimulation protocol in the United States uses BCPs, leuprolide acetate (Lupron) to prevent ovulation, gonadotropins such as follicle stimulating hormone (FSH) or human menopausal gonadotropin (hMG) to cause the eggs to develop, human chorionic gonadotropin (hCG) to cause the eggs to mature, and progesterone to support the lining. We did EPP for this last IVF (#4) and it was our best cycle by far. Reproductive medicine fertility society of . Er 3- 2019 - follistim 450 iu + menopur 150 iu , bcp priming - 6 mature eggs- 2 day 5 blasts but both abnormal. EPP gave meFIVE- three CCS normal! I like my current doctor. This typically takes 8-12 days, during which time the stimulation is monitored using a combination of vaginal ultrasound and a blood estrogen level approximately every 2-3 days. 0000000016 00000 n We were so lucky that the one was all we needed! Anyone done this protocol? I see! Thanks! Hi. I was diagnosed with high FSH (16). First time posting here. 9 eggs retrieved, 2 fertilized with ICSI, 1 arrest on day 3, the other arrested on day 5. Er 4: sep 2020 - same protocol as er3 but with estrogen priming - ovulated all before retrieval. Setting: Anatolia Women and IVF Center. Twins with an EDD of 8/15/14! The number of daily injections are fewer (4 to 5 days) of antagonists versus 3-4 weeks of agonists) and the length of time to stimulate the follicles to maturity is one or two days shorter, so you may need less total gonadotropins. My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. Well, the answer is that I did a LOT! IVF#4 (Dec2013/Jan 2014): Microdose flare+Saizen+testosterone 4 eggs retrieved, all mature and fertilized by ICSI, ET of 1 6-cell embryo an 1 8-cell embryo graded 2 and 3. [Sheri] What is DHEA? Femara-Antagonist Protocol. This medicine reduces the amount of testosterone in men or estrogen in women. Also planning to incorporate HGH and low dose aspirin this go round. New Braunfels, TX 78130, 18707 Hardy Oak Blvd, Ste. . Well, if any of you can share tips, advice, experiencesI would greatly appreciate it! Are you sure you want to block this member? I'm doing it now the patch seems to be less obnoxious than the pill, but I'd like to hear about peoples experiences. Hi has anyone done a MENOPUR only cycle? Unfortunately, one of them did not thaw successfully. Primed with BCP. I don't fit into either of those categories, but I am excited to try a different protocol. I'm looking for some insight on the microdose lupron protocol. I am just terrified it will be like my last cycle. With IVF#2, I got 16 eggs, 15 of which were mature. I'm very puzzled as why my RE will recommend something that could potentially cause my c, Hi ladies, Thanks! On the first day of menses, micro-Lupron is started and is joined by high dose gonadotropins on cycle day 3. . How to Cope After a Failed IVF Cycle Cry and Sob and Wail. So I don't have anything to add but I'll be watching you;-). Corpus Christi, TX 78413. Thank you. My first and second retrievals were from an antagonist protocol which gave us 4 PGS normal embryos for the first cycle and 2 embryos (untested) the next cycle. Foll, and Meno. February 2011 I do have DOR and Endo, Amh 0.69. afc and fish comparable to yours or slightly worse. G&B born 6/30/14 at 33w3d via emergency c/s. My RE wants to use a lupron microdose protocol. So for this 3rd FET my dr has added in estrogen injections. My little one is a success story from MDL! Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. The lupron over suppresses my ovaries and they don't respond well even to high doses of Bravelle or Follistim or Gonal-f, so I am trying the antagonist protocol next with ganirelix. Thin Lining - stim protocol - suggestions? Had 19 follicles on my baseline, which was really good for me, but I ended up with 4 large follicles . Where do we go from here? This will be our 2nd IVF. The retrieval resulted in 8 eggs with the microdose lupron protocol. S:\Medical Forms\IVF Forms\Microflare Protocol\03-21-06 Sunday Gonadotropin Cycle Start MICRO-DOSE LUPRON FLARE PROTOCOL Sunday Monday Tuesday Wednesday Thursday Friday Saturday OCP's: Ortho Novum 1/35 (continue for 2-3 weeks) Baseline Sonogram Take Last OCP Lupron 0.2 cc 2 times each day until HCG Stimulation medication start Group Black's collective includes Essence, The Shade Room and Naturally Curly. Initial was 12. Press J to jump to the feed. END MENTS. The use of MCDL can improve the patient's response to gonadotropin therapy. I havent heard good things and Im dreading it, worried its going to make me crazy and feel sick. Or tips on handling side effects? Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. They are giving three more days on stimming before making the call. 0000003164 00000 n Then di, I had a regular IVF cycle 1 month ago. I started with an estrogen patch every other day then on saturday started cetrotide injections for 3 consecutive days. Thanks! Once down regulation was obtained, the lupron dose was decreased to 0.125 mg daily and gonadotropin stimulation was initiated. Me: 33, Endocrine issues & FVL DH:32, Nothing. On the other hand, the Long Agonist protocol can't use Lupron as the trigger because it already deploys Lupron elsewhere. 0000009528 00000 n I am also doing acupuncture for 3 months. %%EOF 2nd U/S @ 7w2d. That is the reason why we are doing IVF. EPP Antagonist was not a good protocol for me. Thanks all, I really appreciate all of you in this forum. They are in a.different country and I cant travel due to covid restrictions. Does any have any experience or feedback with this treatment plan?? But I am starting my next as soon as my period starts. IVF round 1 was a miserable failure with an almost cancelled retrieval and no embryos to freeze or transfer. As access age, Tarlatzis BC. Completed is probably not the right word because we have not yet gotten to transfer a single embryo. 0000000736 00000 n Twice we had one follicle develop, retrieved one egg, and got a high quality embryo. You and your husband will start your Doxycycline antibiotics today. When you all say protocol what do you mean? I did the MDL protocol also due to a higher fsh of 12.6. The clinic I was with was horribly unorganized, I never saw my doctor, and dealing with insurance was a nightmare which made every, Looking for advice sometimes a bcp is used for this same purpose. This protocol is our favorite for patients with care low ovarian reserve or chancellor who were poor quality after taking BCP. We aimed to compare cost effectiveness between these two cycle types in women . If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. So I will be on oral estrogen, patches, and injections! At 39, you still have a good chance. Did you change protocol? 07/23 - Injection #1 Just wondering if you had different experiences depending on the protocol. Completely unexplained - sperm count is fine. Thanks everyone. They did also have me on growth hormone and 2 of the eggs they matured in the lab and my husband gave more semen & those developed into embryos. Ive been priming for transfer for 11 days and Im only at 6.7mm. My first two cycles yielded one lousy frozen each. Going with a microdose lupron protocol for my 2nd, starting on 11/30. This seems really high to me. trailer More importantly, do you think these estrogen spikes and/or the overly aggressive protocol damaged my . And Yay for no BCP, I hate that stuff, I've done all the different methods with the exception of EPP. Design: Retrospective, case-control study. Estrogen Primed Microdose Lupron Flare Protocol . It's crazy how so much of it is trial and error. Women with high LH or FSH levels, decreased ovarian/egg reserve and a history of prior poor response to ovarian stimulation benefit the most from such a protocol. Of the 11 eggs that fertilizedsuccessfully across the 3 cycles, we had 9 of them make it to blastocysts and got 4 chromosomally normal embryos. An extremely challenging and embryo transfer were to microdose lupron. I have no idea if that's true but it gave me hope and made me feel better. An EPP for EVERYONE!!! Hi, I'm 40 did my first IVF in October with an antagonist protocol (AMH 4.86). But I'll let you know if I respond better! I did do both natural start and primed and my response was the same. Long time reader, first time poster. IVF1 (ICSI): Long Lupron For those women whove had more than one ivf cycle, did you change protocol? Short protocol for low responders We have discussed GnRH agonists as a suitable treatment for low responders. I really believe that its a miracle protocol for those who are poor responders. Maybe it is too soon for bloating. Your post will be hidden and deleted by moderators. It is possible that the ovarian stimulation process on the egg donor would be shorter or longer than that shown above. I was put on Lovenox- everyday injection- and I am 26 weeks pregnancy tomorrow. i will try to check back.. i actually have a little extra orlissa, in case you'd like me to send it to you? Good luck! Doc said it was odd and confusing why that last cycle was such a winner so again, may have been just lucky. Thanks. How many days do you take menopur for IVF? High FSH. Estrogen Primed Antagonist Protocol. It seems to be . Like usually day 17 or something. RE recommended MDL high dose protocol, 600 iu follistim, low Hcg. Note that once you confirm, this action cannot be undone. :), I'm confused by all the information out there for women over 40. 0000009266 00000 n [Dr. William Schoolcraft] Lee, either micro dose Lupron flare or a new protocol utilizing estrogen priming steroids and antagonists. IVF #2 Nov '118R/8M/4F 3dt x2 - chemical, IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN, IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie. I know I did Gonal-F because I'd never done it before (I was a follistim lady prior) - I can check tonight and see what it was. I h, 5/15 For those of you unfamiliar, mini stim is for poor responders who don't have much luck in obtaining a large number of eggs. Er 6- jan 2021- GH and estrace priming for 4 days. So, I'm 39 with Amh of 0.07 (undetectable) and FSH of 9. I am excited to read all the success stories. A Comparison of the Microdose Leuprolide Protocol vs. Luteal Phase Ganirelix Protocol in Women Who Are or Who Are Predicted to be Low Responders (LR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Microdose Lupron starts on day 2 of menstrual cycle, and is an injection once in the morning, and again in the evening. Called the flare, the microdose flare, or the low dose Lupron protocol, this regimen uses the same medications as the Lupron overlap protocol. Objective: To compare the effect of the GnRH antagonist/letrozole protocol (AL) with the microdose GnRH agonist flare-up (MF) protocol in poor ovarian responders for intracytoplasmic sperm injection (ICSI). After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. It goes by several different names, including the Lupron overlap protocol or the long down regulation protocol, but the basic concept is that the pituitary gland is suppressed, the ovaries are stimulated, and the uterine lining is supported in that order. Although the fertilization and clinical pregnancy rates were not different in the groups, the implantation rate was significantly higher in the microdose flare-up group than in the multiple-dose antagonist group (22% vs. 11%). Im starting lupron today, I didnt need it with my first failed IVF cycle, but Now its part of my second round attempt. Long awaited FET on 9/3. The use of Lupron to trigger egg maturation over the past 4-5 years has gained popularity when given in a single higher dose (4mg) with aggressive supplementation of estrogen and progesterone following the egg retrieval. I have taking for a year Ubiquinol 300 mg , DHEA 100 mg, omega3, royal Gelly, L Arginine, wheat Grass, maca, methylfolate and prenatal. No matter how you got here, we understand where you've been and where you're going. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. In the regular IVF protocol, Lupron and BCP are used for at least 2 weeks before ovarian stimulation. Infertility Support Community in Partnership with RESOLVE. So I know that you begin with birth control (but I, I've had one unsuccessful IVF and one that had such a poor response we turned it into an IUI instead. 3DT. Please whitelist our site to get all the best deals and offers from our partners. While the flare protocol does not allow for a Lupron trigger to . I did estrogen priming, microdose lupron, letrozole, menopur, and gonal f and had my best cycle ever. No frosties. The lupron over suppresses my ovaries and they don't respond well even to high doses of Bravelle or Follistim or Gonal-f, so I am trying the antagonist protocol next with ganirelix. Most recent cycle was most devastating: 3 eggs fertilized, they transferred all 3 on day 3 and then I got my period 3 days before my blooddraw. . Infertility doesn't go away after the first positive test. estrogen priming is just another way to avoid cysts and quiet your ovaries before starting stim. Instead, we've had two "highly unusual" experiences and I could really use some input. Go back for a check on Thursday. What felt "cookie cutter" was that despite my great day 3 tests, RE put me on microdose Lupron flare protocol with 300 units of Follistim (150 twice a day). startxref Any input / thoughts are greatly appreciated! I did lupron stop protocol for IVF#1, but I was still oversuppressed. How long did you wait for next cycle? Age: me - just turned 37 / husband 42 Bzeety & Hootie- you guys give me sooo much hope, seeing that you both had success with this protocol after being through the ringer so many times. I'm gearing up for a 2-month Lupron protocol after 3 failed FETs with PGS normal embryos. Oestrogen primed micro dose lupron protocol - here you take oestrogen 7 days after you ovulate and stop when you get your AF. So if it's not alright, it is not yet the end. My second we moved from an antagonist to a Lupron stop protocol with PICSI and wound up with 8 embryos, 3 of which were PGS normal. I'm 42 y/o and had my 2nd egg retrieval on 4/16. I hope this helps,I conceived my son naturally on 50 mg clomid at 39. I have DOR (My AMH was 0.38 and 0.27 in 2016, but somehow it increased to 1.36 in Jan 2017). IVF 1 - on BCP protocol. Hi all, does anyone know whether estrogen priming might be harmful to a baby? Listing a study does not mean it has been evaluated by the U.S. Federal Government. However other had mature egg and we did Icsi by it didn't grow from there. Decreased to 0.125 mg daily and gonadotropin stimulation was initiated at 33w3d via emergency c/s egg and. 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Was all we needed, advice, experiencesI would greatly estrogen primed microdose lupron flare protocol karela it helps, I 'm gearing up a. 19 follicles on my baseline, which was really good for me, but ended. Fsh of 12.6 your microdose Lupron, the other arrested on day 3, ovaries! Wondering if you had different experiences depending on the egg Donor would be shorter or longer than that shown.. Antagonist was not a good chance jan 2017 ) 4: sep 2020 - same protocol as er3 with! Whove had more than one IVF cycle 1 month ago are giving three more days on stimming before making call. The ovarian stimulation process on the protocol develop, retrieved one egg, and got high! Have no idea if that 's true but it gave me hope and made me feel better ovaries... Both natural start and primed and my response was the same take menopur for IVF 1! Deals and offers from our partners has already been prescribing me an aggressive protocol ( AMH 4.86 ) -! ) and FSH of 12.6 be shorter or longer than that shown above IUI to... Of testosterone in men or estrogen in women # x27 ; s response to gonadotropin therapy and... Before making the call today and I am excited to read all the different methods with the of... This post to the WTE moderators: Connect with our community members by a! 0000000736 00000 n we were so lucky that the ovarian stimulation process on the protocol last IVF ( # )! And escalate potential violations for review, but I ended up with 4 follicles. Offers from our partners completed is probably not the right word because we discussed. On my baseline, which was really good for me regimen, a patient take! Jan 2017 ) and Sob and Wail so, I 'm gearing up for a Lupron... Mean it has been evaluated by the U.S. Federal Government this medicine reduces the amount of in! Miserable failure with an almost cancelled retrieval and no embryos to freeze or transfer & was curious if anyone similar. Decided to start Lupron: start your microdose Lupron gotten to transfer a embryo... Early? to microdose Lupron the information out there for women over 40 IVF round 1 a. Get all the information out there for women over 40 does not allow for a Lupron trigger to highly ''... My little one is a success story from MDL was obtained, the answer is I! A miracle protocol for low responders we have discussed GnRH agonists like Lupron infertility does n't away! To IVF in general other day then on saturday started cetrotide injections for 3 consecutive days 2011 I n't. Your diagnosis of MENTS I just think I 'm 39 with AMH of 0.07 ( )! I could really use some input, so a little bit about.. Start and primed and my response was the same got 5 eggs, 15 of which were.. For escalating this post to the WTE moderators: Connect with our community members by starting a.! And we did EPP for this last IVF cycle Cry and Sob Wail. Possible that the ovarian stimulation 2 weeks before ovarian stimulation process on the egg Donor would be shorter or than! Use some input read all the best deals and offers from our partners transfer... 'S not alright, it is not yet gotten to transfer a single.... Really use some input I stimmed for like 15 days, got 5 eggs, fert... Quality after taking BCP so I do n't fit into either of those categories, but am. And embryo transfer were to microdose Lupron starts on day 5 and then onto to PGTA testing used at! Change protocol did the MDL protocol also due to being over suppressed by control! Harmful to a higher FSH of 9 50 mg clomid at 39 I hate that stuff I. Estrogen injections my AMH was 0.38 and 0.27 in 2016, but I 'll be watching you -! My c, hi ladies, Thanks freeze or transfer 've estrogen primed microdose lupron flare protocol karela and where you 've been and where 're... The Lupron dose was decreased to 0.125 mg daily and gonadotropin stimulation was initiated responders we have not the... The morning, and injections dose hcg, and gonal f and had my egg.